Skin Allergy

Description: The research line aims to investigate the immunological mechanisms involved in skin / respiratory allergies, using experimental models. As well as the application and development of investigation methods in the allergic processes of skin expression (angioedema, urticaria, contact dermatitis, pharmacoderma), its immunomodulation and therapeutics.

Understands the projects:

  • Respiratory and skin allergy: study models

  • Skin allergy: therapeutic trials:

  • Contact and occupational dermatitis

  • Pharmacodermias (adverse drug reaction)

  • Cutaneous immunomodulation

Skin Autoimmunity

Description: This line of research aims to study the clinical, immunological, pathogenic, therapeutic response, and primary autoimmune cutaneous diseases or with skin involvement.

Understands the projects:

  • Wild Fire - Pathogenic aspects and Wild Fire Research Cooperative Group

  • Immunopathogenesis of Subepidermal Autoimmune Bullous Dermatoses

  • Research on Collagenoses

Characterization of Cutaneous Tissue Response

Description: In this line of research, we intend to investigate the participation of the cellular elements of the Lymphoid System Associated with the Skin, adhesion molecules and cytokines, in addition to the structural and functional changes of the extracellular matrix, for the characterization of the cutaneous tissue response in inflammatory processes. , infectious and neoplastic. The applied methodology consists of histopathological techniques, special staining techniques, immunohistochemistry (phenotyping of cellular elements, demonstration of adhesion molecules and cytokines, growth factors and mediators of integrity and damage to the extracellular matrix), molecular biology and morphometric methods for quantification in situ.

Understands the projects:

  • Dendritic cells in the cutaneous tissue response

  • Extracellular matrix - peculiar cutaneous aspects

  • Immunophenotypic and functional characterization of the elements, cellular and molecular, involved in the integumentary tissue response

Infectious and Parasitic Dermatoses - Pathogenic Aspects

Description: Skin involvement by infectious and parasitic diseases is very frequent. The skin has its own mechanisms against the aggression of infectious agents. The objective of this line of research is to investigate the pathogenic mechanisms of infectious and parasitic dermatoses, in morphological, immunological and molecular aspects, as well as the investigation of new therapeutic agents and their effects.

This line of research comprises the projects:

  • Mycoses of dermatological interest: pathogenesis, pathology and immunopathology

  • Cutaneous leishmaniasis: pathogenesis, pathology and immunopathology

  • AIDS

  • Tuberculosis and Mycobacterioses

  • Research on sexually transmitted diseases

  • Leprosy

  • Dermatovirosis

Genodermatoses

Description: Genodermatoses comprise diseases of genetic inheritance that affect the skin in an expressive way. They are often rare diseases, but they take on importance due to their severity (such as neurocutaneous syndromes), potential for individuals' disability and interference with quality of life. In our country, due to the existence of geographic and cultural niches, favorable to the event of consanguinity, these diseases are observed with some frequency. With this line of research, it is intended to study genodermatoses in their clinical, epidemiological and therapeutic aspects.  

Understands the projects:

  • Identification, characterization and comparison of unusual genodermatoses in our environment

  • Ichthyosis - evaluation of the therapeutic efficacy of retinoic acid derivatives in keratinization disorders

Invasive Methods in Dermatological Therapy

Description: Genodermatoses comprise diseases of genetic inheritance that affect the skin in an expressive way. They are often rare diseases, but they take on importance due to their severity (such as neurocutaneous syndromes), potential for individuals' disability and interference with quality of life. In our country, due to the existence of geographic and cultural niches, favorable to the event of consanguinity, these diseases are observed with some frequency. With this line of research, it is intended to study genodermatoses in their clinical, epidemiological and therapeutic aspects.

Understands the projects:

  • Identification, characterization and comparison of unusual genodermatoses in our environment

  • Ichthyosis - evaluation of the therapeutic efficacy of retinoic acid derivatives in keratinization disorders

Cutaneous Oncology

Description: The research line aims to investigate the clinical, epidemiological, histopathological, immunopathological and molecular aspects of non-melanoma skin cancer, melanomas, lymphoproliferative processes of the skin and mesenchymal neoplasms.

Understands the projects:

  • Biological, morphological, immunophenotypic and molecular aspects of non-melanoma skin cancer

  • Verruciform epidermodysplasia as a model of cutaneous viral oncogenesis

  • Investigation of melanocytic lesions and malignant melanoma

  • Investigation in cutaneous lymphomas

  • Investigation in mesenchymal neoplasms of the skin

  • The skin as an expression of paraneoplastic manifestations